Found it! In case anyone else wondered
HttpContext.Current.Response.Clear()
HttpContext.Current.Response.ContentType = "application/vnd.openxmlformats-officedocument.spreadsheetml.sheet"
HttpContext.Current.Response.AddHeader("content-disposition", "attachment;filename=AddingDataSet.xlsx")
Using memoryStream As New MemoryStream()
workbook.SaveAs(memoryStream)
memoryStream.WriteTo(HttpContext.Current.Response.OutputStream)
memoryStream.Close()
End Using
HttpContext.Current.Response.[End]()